Libocedroquinone: A Promising Anticancer Lead against Lung Cancer from Calocedrus Decurrens

Abstract A focus on evaluating anticancer potency of various extracts the heartwood Calocedrus decurrens against human lung adenocarcinoma (A549) cell line was performed using in vitro MTT assay. The hexane extract displayed excellent cytotoxic effect, and phytochemical investigation acetone resulted isolation five major compounds. structure compounds established as libocedrol (1), thymoquinone (2), libocedroquinone (3), diethylphthalate (4), (1 R, 2 4 R)-p-menthane-1,2,4-triol (5). Compounds 5 are reported for first time from genus. 1–3 were evaluated their cytotoxicity cancer along with a healthy control. Compound 3 more potent than other A549 an IC50 4.8 µM at 24 h. Moreover, compound exhibited less toxicity normal fibroblast WI-38. This is study species decurrens.